microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. 6 1 0 obj Find answers in our support articles. It is a white, free-flowing powder. Synonyms: Cellulose, Cellulose powder, Cotton linters. Microcrystalline Cellulose E460 MSDS 1. ( Chemical Formula: (C6H10O5)n 1.4. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. Avicel PC 611 Microcrystalline Cellulose. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. % ). cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Molecular weight: Not Applicable 1.5. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. q9;v80q>jZ . Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. . SUBSTANCE IDENTIFICATION 1.1. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. %PDF-1.4 Document(s): certificate data msds. >> TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Eur., JPE . Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. P}MFbN#[>r(y PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. It is available in different grades and particle sizes. These grades have particle sizes ranging from <30 to approximately 200. 0.25 - 0.37. << 1. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Manufactured by: China . JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. Validity Area. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. . The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Microcrystalline Cellulose. In large quantities it provides dietary bulk and may lead to a laxative effect. Avicel PC 611 (FMC Biopolymer) . If you are already a ChemPoint customer then sign up for access to our online ordering website. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Alginates from IFF are an excellent choice for consistent performance in a variety of applications. xv}O2' H~KEe9>G/,:9\i FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . undefined. <> 8 0 obj %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz 1.3. Product Name Cellulose microcrystalline. CAS 9004-34-6, pH 5 - 7.5. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. <> Browse Avicel PH-101 and related products at MilliporeSigma. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. %PDF-1.3 Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Quantity: 1 700 kgs. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. 4 0 obj Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. common form is used in vitamin supplements or tablets. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? No. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. stream Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. EMCOCEL XLM 90. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. Date Approved: 05/25/2010. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Have an order or account question, find answers in our Online Support articles. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Catalog Number 102331. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against INCI. It is also used in plaque assays for counting. Fiber supplements can lessen the absorption of some . It . All rights reserved. Packaging: 34 x 50 kgs fiber drums. SUBSTANCE IDENTIFICATION 1.1. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. G2W4de=u183KGH{ vQ#4:1\wc Well-recognized product that can do it all. Avicel Microcrystalline Cellulose Physical Properties. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. endobj Learn about FMC's differentiated biologically-based crop solutions. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Cellulose microcrystalline. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. PharmaCentral 2021 . Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. Buy Chemicals. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. We respect your privacy FMC Privacy Policy. In 1964 FMC, Corporation . The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. CAS No. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. Instead, they obtained a stable colloidal suspension. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . The data shown below apply only to Avicel PH 101. It works as a moisture sponge and permits the controlled growth of spheroids. Request media, explore upcoming events and read our latest updates. The cellulose molecule is formed through repeated condensation of cellobiose units. The table below shows the most common physicochemical parameters of this raw material. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. Wu, K. Zuurman, H.W. 4 0 obj Combines good flow and high compactibility. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Product Name: Microcrystalline Cellulose 1.2. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> The figure below illustrates the structural organisation of cellulose within plants. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . By producing Avicel . % Product and Company Identification . Production of Pharmaceutical Grade Microcrystalline Cellulose. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Microcrystalline Cellulose / Avicel PH-102. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. HMo@9, U Q!R/1*;` %PDF-1.4 stream Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Page 1 of 8. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b An agricultural sciences company. << Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? Heavy metals, % NMT 0.001 ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? It is . CAS #: 9004-34-6 1.6. Van Veen, G.K. Bolhuis, Y.S. (1962). In extrusion-spheronisation, it is the excipient of choice. Avicel PC 611 (FMC Biopolymer) Supplied by. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. : 1. Explore how we work and why we apply science and creativity for a better world to everything we do. Report Category. . /Resources 2 0 R The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Microcrystalline Cellulose; Cellulose; Functions. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. 9,LL!z Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. Created Date: 2/10/2020 8:51:41 PM . If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. 2021 Annual Report. Earth Supplied Products LLC. 1.3. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. Alginates also function as actives in some anti-reflux products. Manufacturer: FMC BioPolymer. Microcrystalline Cellulose NF. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. All Rights Reserved. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Avicel RC-591 & CL-611 - Description. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Apply today! MATERIAL SAFETY DATA SHEET Version: 1.0 1. Avicel PH-101. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. No. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ We know that our customers need to provide reliable and consistent products to their patients. CoA. 51395-75-6 Avicel RC 591. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. Avicel Microcrystalline Cellulose: Chemical Identifiers. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used.